7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7 Purity >99.0% (HPLC) Ivabradine Hydrochloride Intermediate Factory

Short Description:

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

CAS: 73942-87-7

Purity: >99.0% (HPLC)

Appearance: Off-White to White Powder

Intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6)

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Product Detail

Product Tags

Ivabradine Hydrochloride Intermediates:

Ruifu Chemical Supply Ivabradine Hydrochloride Intermediates With High Purity
Ivabradine Hydrochloride CAS 148849-67-6
4,5-Dimethoxy-1-Cyanobenzocyclobutane CAS 35202-54-1
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride CAS 866783-13-3
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one CAS 148870-57-9
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one CAS 85175-59-3

73942-87-7 - Chemical Properties:

Chemical Name	7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Synonyms	Ivabradine Hydrochloride Intermediate; 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one; 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one; 1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one; Intermediate of IVA 5; Ivabradine Impurity 13
CAS Number	73942-87-7
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C12H13NO3
Molecular Weight	219.24
Density	1.167
Melting Point	244.0~248.0℃
COA & MSDS	Available
Shelf Life	>2 Years if Stored Properly
Place of Origin	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

73942-87-7 - Specifications:

Item	Specifications	Results
Appearance	Off-White to White Powder	Off-White Powder
Identification	HPLC / UV	Complies
Purity / Analysis Method	>99.0% (HPLC)	99.54%
Melting Point	244.0~248.0℃	244.0~248.0℃
Loss on Drying	<0.50% (Dry it at 60℃ in vacuum till a constant weight)	0.18%
Residue on Ignition	<0.10%	0.06%
Related Substances
Individual Impurity	<0.50%	<0.50%
Total Impurities	<1.00%	0.46%
Heavy Metals	<10ppm	<10ppm
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6)

73942-87-7 - Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

73942-87-7 - FAQ:

73942-87-7 - Application:

7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one (CAS: 73942-87-7) is an intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6). Ivabradine Hydrochloride, also known as S-16257, is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolarization-activated If current without resulting in a shift of the voltage range of the activation curve.